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商品详细Hello Bio/PD 98059/HB2244/1mg

Hello Bio/PD 98059/HB2244/1mg

商品编号： HB2244-1mg

品牌： hellobio

市场价： ¥409.50

美元价： 315.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

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商品介绍

Productoverview

Name
PD98059
Shortdescription
SelectiveMEK1/MAP2Kinhibitor.EnhancesESCself-renewal.
BIOLOGicaldescription
SelectiveMEK1/MAP2Kinhibitor(IC₅₀valuesare2and50µMatMEK1andMEK2respectively).BindstoinactivatedMEKtopreventitsphosphorylationbyMEKkinaseorc-Raf.Inhibitscellgrowthandproliferationandinducesmodestapoptosis.Alsoenhancesembryonicstemcellself-renewal.Activeinvivo.
Biologicalaction
Inhibitor
Purity
>98%
Ourproductsinaction
1citationSubmitYourCitationNow

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Properties

Chemicalname
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
MolecularWeight
267.28
Chemicalstructure
MolecularFormula
C₁₆H₁₃NO₃
CASNumber
167869-21-8
PubChemidentifier
4713
SMILES
COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
InChi
InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h4-9H,17H2,1H3
InChiKey
QFWCYNPOPKQOKV-UHFFFAOYSA-N
MDLnumber
MFCD00671789

StoringandUsingYourProduct

Storageinstructions
Roomtemperature
Solubilityoverview
SolubleinDMSO(25mM)andinethanol(5mM)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforPD98059

PD098059isaspecificinhibitoroftheactivationofmitogen-activatedproteinkinasekinaseinvitroandinvivo.
AlessiDRetal(1995)JBiolChem270(46):27489-94.
PubMedID:7499206
Asyntheticinhibitorofthemitogen-activatedproteinkinasecascade.
DudleyDTetal(1995)ProcNatlAcadSciUSA92(17):7686-9.
PubMedID:7644477
U0126andPD98059,specificinhibitorsofMEK,acceleratedifferentiationofRAW264.7cellsintoosteoclast-likecells.
HotokezakaHetal(2002)JBiolChem277(49):47366-72.
PubMedID:12237315
InhibitionofMAPkinasekinaseblocksthedifferentiationofPC-12cellsinducedbynervegrowthfactor.
PangLetal(1995)JBiolChem270(23):13585-8.
PubMedID:7775407
Pre-LTPrequiresextracellularsignal-regulatedkinaseintheACC.
Yamanakaetal(2016)MolPain12:1-12
PubMedID:27178245

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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