Hello Bio/PD 0325901/HB2240/50mg
商品编号：
HB2240-50mg
品牌：
hellobio
市场价：
¥7273.50
美元价：
5595.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePD0325901
- ShortdescriptionPotentMEK1andMEK2inhibitor.EnhancesiPSCsgeneration.
- BIOLOGicaldescription
Potent,non-ATPcompetitiveMEK1(MKK1)andMEK2(MKK2)inhibitor(Kivaluesare0.79and1.1nMatMEK1andMEK2respectively).
Cellpermeable.
InducesG1-phasecellcyclearrestandapoptosisandinhibitsmelanomacelllinegrowthinvitroandinvivo.
IncreasesreprogrammingefficiencyofhumanprimaryfibroblastsintoiPSCswhencombinedwithSB431542andalsopreventscelldifferentiationandsustainsself-renewalofESCswhencombinedwithCHIR99021
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
- MolecularWeight482.19
- Chemicalstructure
![PD 0325901 | PD325901 [391210-10-9]](images/hellobio/201710/hb2240.png "PD 0325901 | PD325901 [391210-10-9]")
- MolecularFormulaC16H14F3IN2O4
- CASNumber391210-10-9
- PubChemidentifier9826528
- SMILESC1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
- InChiInChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
- InChiKeySUDAHWBOROXANE-SECBINFHSA-N
- MDLnumberMFCD08435926
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewSolubleinDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPD0325901
AchemicalplatformforimprovedinductionofhumaniPSCs.
Linetal(2009)NatMethods6(11):805-8PubMedID:19838168Thegroundstateofembryonicstemcellself-renewal.
Yingetal(2008)Nature453(7194):519-23PubMedID:18497825ThediscoveryofthebenzhydroxamateMEKinhibitorsCI-1040andPD0325901.
Barrettetal(2008)BioorgMedChemLett18(24):6501-4.PubMedID:18952427Growth-inhibitoryandantiangiogenicactivityoftheMEKinhibitorPD0325901inmalignantmelanomawithorwithoutBRAFmutations.
Ciuffredaetal(2009)Neoplasia11(8):720-31.PubMedID:19649202
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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