Hello Bio/PCI 34051/HB1393/50mg
商品编号：
HB1393-50mg
品牌：
hellobio
市场价：
¥6610.50
美元价：
5085.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePCI34051
- ShortdescriptionPotent,selectiveHDAC8inhibitor
- BIOLOGicaldescriptionPotentandselectivehistonedeacetylase8(HDAC8)inhibitor(IC50=10nM).Shows>200-foldselectivityoverotherHDACisoforms(IC50valuesare2.9,4,13,>50and>50µMforHDAC6,1,10,2and3respectively).Showsapoptoticandanti-canceractions.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
- MolecularWeight296.32
- Chemicalstructure
![PCI 34051 [950762-95-5]](images/hellobio/201710/hb1393.png "PCI 34051 [950762-95-5]")
- MolecularFormulaC17H16N2O3
- CASNumber950762-95-5
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinNaOH(aq)(20mM,1eq.NaOH)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPCI34051
Anovelhistonedeacetylase8(HDAC8)-specificinhibitorPCI-34051inducesapoptosisinT-celllymphomas.
BalasubramanianSetal(2008)Leukemia22(5):1026-34.PubMedID:18256683HDAC8-mediatedepigeneticreprogrammingplaysakeyroleinresistancetoanthraxlethaltoxin-inducedpyroptosisinmacrophages.
HaSDetal(2014)JImmunol193(3):1333-43.PubMedID:24973453Design,synthesis,andevaluationofhydroxamicacid-basedMolecularprobesforinvivoimagingofhistonedeacetylase(HDAC)inbrain.
WangCetal(2013)AmJNuclMedMolImaging4(1):29-38.PubMedID:24380043
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
