Hello Bio/Paxilline/HB1056/5mg
商品编号：
HB1056-5mg
品牌：
hellobio
市场价：
¥1423.50
美元价：
1095.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePaxilline
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Short descriptionPotent, reversible, selective KCa channel inhibitor. Also SERCA inhibitor.
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Biological descriptionPotent, reversible and selective KCa channel inhibitor (Ki = 1.9 nM at α-subunit). Also sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor (IC50 = 5-50 µM). Indole alkaloid mycotoxin from Penicillium paxilli. Displays anticonvulsant properties.
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, 7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-h ydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 '',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
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Molecular Weight435.56
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Chemical structure
![Paxilline [57186-25-1]](images/hellobio/201710/hb1056.png "Paxilline [57186-25-1]")
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Molecular FormulaC27H33NO4
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CAS Number57186-25-1
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Paxilline
Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.
Zhou Y et al (2010) J Gen Physiol 135(5) : 481-94.PubMedID: 20421373The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline.
Bilmen JG et al (2002) Arch Biochem Biophys 406(1) : 55-64.PubMedID: 12234490Anticonvulsant effects of the BK-channel antagonist paxilline.
Sheehan JJ et al (2009) Epilepsia 50(4) : 711-20.PubMedID: 19054419Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel.
Sanchez M et al (1996) Neuropharmacology 35(7) : 963-8.PubMedID: 8938726
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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