Hello Bio/Paroxetine hydrochloride/HB0478/50mg
商品编号：
HB0478-50mg
品牌：
hellobio
市场价：
¥4680.00
美元价：
3600.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameParoxetinehydrochloride
- ShortdescriptionPotent,selectiveSEROtoninreuptakeinhibitor.SelectiveGRK2inhibitor.
- BIOLOGicaldescriptionPotentandselectiveserotonin(5-HT)reuptakeinhibitor(Ki=0.05nM).Bindstotheserotonintransporter(SERT).AlsoinhibitsNorepinephrinetransporter(NET)andincreasesNETandSERTexpression.AdditionallyactsasaselectiveG-protein-receptor-kinase2(GRK2)inhibitor,showing>50-foldselectivityoverotherGRKs.Showsantidepressantandanxiolyticactions.
- AlternativenamesPaxil
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
- MolecularWeight365.82
- Chemicalstructure
![Paroxetine HCl [78246-49-8]](images/hellobio/201710/hb0478.png "Paroxetine HCl [78246-49-8]")
- MolecularFormulaC19H21ClFNO3
- CASNumber78246-49-8
- PubChemidentifier62878
- SMILESC1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
- InChiInChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1
- InChiKeyGELRVIPPMNMYGS-RVXRQPKJSA-N
- MDLnumberMFCD03658863
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforParoxetinehydrochloride
Neurotransmitterreceptorandtransporterbindingprofileofantidepressantsandtheirmetabolites.
OwensMJetal(1997)JPharmacolExpTher283(3):1305-22.PubMedID:9400006Antidepressiveeffectofparoxetineinaratmodel:upregulatingexpressionofserotoninandnorepinephrinetransporter.
QiuHMetal(2013)Neuroreport24(10):520-5.PubMedID:23636256Neuropharmacologyofparoxetine.
NemeroffCBetal(2003)PsychopharmacolBull37Suppl1:8-18.PubMedID:14566196
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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