Hello Bio/Ouabain/HB1140/100mg
商品编号：
HB1140-100mg
品牌：
hellobio
市场价：
¥663.00
美元价：
510.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameOuabain
- ShortdescriptionSelectiveNa+/K+ATPaseinhibitor
- BIOLOGicaldescriptionSelectiveNa+/K+ATPaseinhibitor.Thoughttoactasaproliferativeagent;promotescardiacandvascularmyocytecellgrowth.Showspositiveinotropic,vasoconstrictiveandhypertensiveactions.
- Alternativenamesg-strophanthin
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
- MolecularWeight584.66
- Chemicalstructure
![Ouabain [630-60-4]](images/hellobio/201710/hb1140.png "Ouabain [630-60-4]")
- MolecularFormulaC29H44O12.8H2O
- CASNumber630-60-4
- PubChemidentifier439501
- SMILESC[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O
- InChiInChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28
- InChiKeyLPMXVESGRSUGHW-HBYQJFLCSA-N
- MDLnumberMFCD00149240
- AppearanceWhitesolid
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinwater(10mM)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforOuabain
Effectofm-calpaininPKCalpha-mediatedproliferationofpulmonaryarterysmoothmusclecellsbylowdoseofouabain.
ShaikhSetal(2013)IndianJBiochemBiophys50(5):419-27.PubMedID:24772963Increasedconstrictortoneinducedbyouabaintreatmentinrats.
PulgarVMetal(2013)JCardiovascPharmacol62(2):174-83.PubMedID:23615157DifferentrolesofthecardiacNa+/Ca2+-exchangerinouabain-inducedinotropy,cellsignaling,andhypertrophy.
BaiYetal(2013)AmJPhysiolHeartCircPhysiol304(3):H427-35.PubMedID:23203972
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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