Hello Bio/Oncrasin 1/HB0473/50mg
商品编号：
HB0473-50mg
品牌：
hellobio
市场价：
¥4914.00
美元价：
3780.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameOncrasin 1
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Short descriptionSmall molecule RNA polymerase II inhibitor
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Biological descriptionSmall molecule RNA polymerase II inhibitor. Also induces dose-dependent cytotoxicity (IC50 = 4.81 µM) and disrupts interaction of PKCι and cyclin-dependent protein kinase 9/cyclin T1 complex. Anticancer agent that induces apoptosis. Displays antiproliferative properties.
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
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Molecular Weight269.73
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Chemical structure
![Oncrasin 1 [75629-57-1]](images/hellobio/201710/hb0473.png "Oncrasin 1 [75629-57-1]")
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Molecular FormulaC16H12ClNO
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CAS Number75629-57-1
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in DMSO (100mM) or ethanol (25mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Oncrasin 1
Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.
Wu S et al (2011) J Med Chem 54(8) : 2668-79.PubMedID: 21443218Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
Guo W et al (2008) Cancer Res 68(18) : 7403-8.PubMedID: 18794128Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
Guo W et al (2009) Mol Cancer Ther 8(2) : 441-8.PubMedID: 19208825
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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