Hello Bio/ω-Agatoxin IVA/HB1212/100μg
商品编号：
HB1212-100μg
品牌：
hellobio
市场价：
¥3997.50
美元价：
3075.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Nameω-AgatoxinIVA
- ShortdescriptionPotent,selectiveP-type/Q-typeCa2+channelblocker
- BIOLOGicaldescriptionPotentandselectiveP-type/Q-typeCa2+channelblocker(IC50=<1-3 nm="" for="" p="" type="" channels).="" exhibits="" reduced="" potency="" at="" n-type="">2+channels.FoundinthevenomofthefunnelwebspiderAgelenopsisaperta.
- BiologicalactionBlocker
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameH-DL-Lys-DL-Lys-DL-Lys-DL-Cys(1)-DL-xiIle-DL-Ala-DL-Lys-DL-Asp-DL-Tyr-Gly-DL-Arg-DL-Cys(2)-DL-Lys-DL-Trp-Gly-Gly-DL-xiThr-DL-Pro-DL-Cys(3)-DL-Cys(1)-DL-Arg-Gly-DL-Arg-Gly-DL-Cys(2)-DL-xiIle-DL-Cys(4)-DL-Ser-DL-xiIle-DL-Met-Gly-DL-xiThr-DL-Asn-DL-Cys(4)-DL-Glu-DL-Cys(3)-DL-Lys-DL-Pro-DL-Arg-DL-Leu-DL-xiIle-DL-Met-DL-Glu-Gly-DL-Leu-Gly-DL-Leu-DL-Ala-OH
- MolecularWeight5202.25
- MolecularFormulaC217H360N68O60S10
- CASNumber145017-83-0
- PubChemidentifier90488780
- SMILESCCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)C(C)CC)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N)C(=O)NC(CCCCN)C(=O)N9CCCC9C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)C(C)CC)CCSC)C(C)O)CC(=O)N
- InChiInChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-34
- InChiKeyNVVFOMZVLALQKT-UHFFFAOYSA-N
- MDLnumberMFCD00165055
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinwater
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesforω-AgatoxinIVA
Synthesisofomega-agatoxinIVAanditsrelatedpeptides.
NishioHetal(1993)BiochemBiophysResCommun196(3):1447-53.PubMedID:8250902Differentialresponsestoω-agatoxinIVAinmurinefrontalcortexandspinalcordderivedneuronalnetworks.
KnaackGLetal(2013)Neurotoxicology37:19-25.PubMedID:23523780Proteasetreatmentofcerebellarpurkinjecellsrendersomega-agatoxinIVA-sensitiveCa2+channelsinsensitivetoinhibitionbyomega-conotoxinGVIA.
TringhamEWetal(2008)JPharmacolExpTher324(2):806-14.PubMedID:17975010
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
