Hello Bio/Okadaic Acid/HB0468/
市场价：
¥877.50
美元价：
675.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameOkadaic Acid
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Short descriptionPotent, non-competitive protein phosphatase inhibitor
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Biological descriptionPotent and non-competitive protein phosphatase inhibitor. Exhibits higher selectivity for PP2A and PP1 over PCM (purified polycation-modulated) phosphatase and PP2B (ID50 values are 1.2, 315, 205 and 4530 nM respectively) yet little or no activity at PP2C. Displays apoptosis inducing properties with neurotoxic and tumor promoting effects. A diarrheic shellfish poisoning (DSP) toxin.
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Alternative namesOA
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name9,10-Deepithio-9,10-didehydroacanthifolicin
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Molecular Weight805.01
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Chemical structure
![Okadaic Acid [78111-17-8]](images/hellobio/201710/hb0468.png "Okadaic Acid [78111-17-8]")
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Molecular FormulaC44H68O13
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CAS Number78111-17-8
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PubChem identifier446512
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SMILESC[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
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InChiInChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,
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InChiKeyQNDVLZJODHBUFM-WFXQOWMNSA-N
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MDL numberMFCD00083455
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewSoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Okadaic Acid
Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.
Haneji T et al (2013) Int J Oncol 42(6) : 1904-10.PubMedID: 23591640Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.
Bialojan C et al (1988) Biochem J 256(1) : 283-90.PubMedID: 2851982Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.
Standaert ML et al (1999) J Biol Chem 274(20) : 14074-8.PubMedID: 10318822Okadaic acid: more than a diarrheic toxin.
Valdiglesias V et al (2013) Mar Drugs 11(11) : 4328-49.PubMedID: 24184795
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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