Hello Bio/Okadaic Acid/HB0468/100μg
商品编号：
HB0468-100μg
品牌：
hellobio
市场价：
¥2418.00
美元价：
1860.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameOkadaicAcid
- ShortdescriptionPotent,non-competitiveproteinphosphataseinhibitor
- BIOLOGicaldescriptionPotentandnon-competitiveproteinphosphataseinhibitor.ExhibitshigherselectivityforPP2AandPP1overPCM(purifiedpolycation-modulated)phosphataseandPP2B(ID50valuesare1.2,315,205and4530nMrespectively)yetlittleornoactivityatPP2C.Displaysapoptosisinducingpropertieswithneurotoxicandtumorpromotingeffects.Adiarrheicshellfishpoisoning(DSP)toxin.
- AlternativenamesOA
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname9,10-Deepithio-9,10-didehydroacanthifolicin
- MolecularWeight805.01
- Chemicalstructure
![Okadaic Acid [78111-17-8]](images/hellobio/201710/hb0468.png "Okadaic Acid [78111-17-8]")
- MolecularFormulaC44H68O13
- CASNumber78111-17-8
- PubChemidentifier446512
- SMILESC[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
- InChiInChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,
- InChiKeyQNDVLZJODHBUFM-WFXQOWMNSA-N
- MDLnumberMFCD00083455
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforOkadaicAcid
OkadaicacidactivatesthePKRpathwayandinducesapoptosisthroughPKRstimulationinMG63osteoblast-likecells.
HanejiTetal(2013)IntJOncol42(6):1904-10.PubMedID:23591640Inhibitoryeffectofamarine-spongetoxin,okadaicacid,onproteinphosphatases.Specificityandkinetics.
BialojanCetal(1988)BiochemJ256(1):283-90.PubMedID:2851982OkadaicacidactivatesatypicalproteinkinaseC(zeta/lamBDa)inratand3T3/L1ADIpocytes.AnapparentrequirementforactivationofGlut4translocationandglucosetransport.
StandaertMLetal(1999)JBiolChem274(20):14074-8.PubMedID:10318822Okadaicacid:morethanadiarrheictoxin.
ValdiglesiasVetal(2013)MarDrugs11(11):4328-49.PubMedID:24184795
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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