Hello Bio/NSC 74859/HB1436/25mg
商品编号：
HB1436-5mg
品牌：
hellobio
市场价：
¥1072.50
美元价：
825.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNSC74859
- ShortdescriptionSelectiveSTAT3inhibitor
- BIOLOGicaldescriptionSelectiveSTAT3DNA-bindinginhibitor.SelectivelyinhibitsSTAT3-STAT3overSTAT1-STAT3andSTAT1-STAT1DNA-binding(IC50valuesare86,160and>300µMrespectively).Enhancestheactivityofcytotoxicdrugs.Showsantiproliferative,apoptoticandanti-tumoractions.
- AlternativenamesS3I-201
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoicacid
- MolecularWeight365.36
- Chemicalstructure
![NSC 74859 [501919-59-1]](images/hellobio/201710/hb1436.png "NSC 74859 [501919-59-1]")
- MolecularFormulaC16H15NO7S
- CASNumber501919-59-1
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNSC74859
SelectivechemicalprobeinhibitorofStat3,identifiedthroughstructure-basedvirtualscreening,inducesantitumoractivity.
SiddiqueeKetal(2007)ProcNatlAcadSciUSA104(18):7391-6.PubMedID:17463090NSC74859-mediatedinhibitionofSTAT3enhancestheanti-proliferativeactivityofcetuximabinhepatocellularcarcinoma.
ChenWetal(2012)LiverInt32(1):70-7.PubMedID:22098470NSC74859enhancesdoxorubicincytotoxicityviainhibitionofepithelial-mesenchymaltransitioninhepatocellularcarcinomacells.
HuQDetal(2012)CancerLett325(2):207-13.PubMedID:22781398
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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