Hello Bio/NSC 33994/HB1430/50mg
商品编号：
HB1430-50mg
品牌：
hellobio
市场价：
¥5674.50
美元价：
4365.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNSC33994
- ShortdescriptionPotent,selectiveJAK2inhibitor
- BIOLOGicaldescriptionPotentandselectiveJAK2inhibitor(IC50=60nM).Showsanti-neoplasticactions.
- AlternativenamesG6
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameE-4,4"-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
- MolecularWeight438.65
- Chemicalstructure
![NSC 33994 [82058-16-0]](images/hellobio/201710/hb1430.png "NSC 33994 [82058-16-0]")
- MolecularFormulaC28H42N2O2
- CASNumber82058-16-0
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(5mM,gentlewarming)orethanol(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNSC33994
IdentificationofanovelinhibitorofJAK2tyrosinekinasebystructure-basedvirtualscreening.
KissRetal(2009)BioorgMedChemLett19(13):3598-601.PubMedID:19447617TheJak2smallmoleculeinhibitor,G6,reducesthetumOrigenicpotentialofT98Gglioblastomacellsinvitroandinvivo.
BaskinRetal(2014)PLoSOne9(8):e105568.PubMedID:25162558TheJak2inhibitor,G6,alleviatesJak2-V617F-mediatedmyeloproliferativeneoplasiabyprovidingsignificanttherapeuticefficacytothebonemarrow.
KiraboAetal(2011)Neoplasia13(11):1058-68.PubMedID:22131881
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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