你好Bio/NPC-15437二盐酸盐/HB0457/10mg
商品编号：
HB0457-10mg
品牌：
hellobio
市场价：
¥3919.50
美元价：
3015.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNPC-15437dihydrochloride
- ShortdescriptionCompetitive,selectivePKCinhibitor
- BIOLOGicaldescriptionCompetitiveandselectiveproteinkinaseC(PKC)inhibitor(IC50=19.0µM)thatinteractsatNterminalofC1domain.ShowsselectivityforPKC-αoverPKC-HHandPKC-CB(IC50valuesare22,30,130µMrespectively).ExhibitslittleornoactivityforcAMP-dependentorcalcium/calmodulin-dependentproteinkinase(IC50values>300µM).Displaysneuroprotectiveproperties.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- MolecularWeight511.62
- Chemicalstructure
![NPC-15437 dihydrochloride [136449-85-9]](images/hellobio/201710/hb0457.png "NPC-15437 dihydrochloride [136449-85-9]")
- MolecularFormulaC25H50N4O2.2HCl
- CASNumber136449-85-9
- PubChemidentifier16219723
- SMILESCCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@H](CCCCN)N.Cl.Cl
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinwaterorDMSO
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNPC-15437dihydrochloride
2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide(NPC15437):aselectiveinhibitorofproteinkinaseC.
SullivanJPetal(1991)AgentsActions34(1-2):142-4.PubMedID:17930192,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide(NPC15437):anovelinhibitorofproteinkinaseCinteractingattheregulatorydomain.
SullivanJPetal(1992)MolPharmacol41(1):38-44.PubMedID:1732721NPC15437interactswiththeC1domainofproteinkinaseC.AnanalysisusingmutantPKCconstructs.
SullivanJPetal(1991)FEBSLett285(1):120-3.PubMedID:2065775TheselectiveproteinkinaseCinhibitor,NPC15437,inducesspecificdeficitsinmemoryretentioninmice.
MathisCetal(1992)EurJPharmacol220(1):107-10.PubMedID:1425976
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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