Hello Bio/L-NMMA/HB1353/5mg
商品编号：
HB1353-5mg
品牌：
hellobio
市场价：
¥429.00
美元价：
330.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameL-NMMA
- ShortdescriptionCompetitive,selectiveNOSinhibitor
- BIOLOGicaldescriptionCompetitiveandselectivenitricoxidesynthase(NOS)inhibitor(IC50valuesare6.6,4.9and3.5μMforiNOS,nNOSandeNOSrespectively).AlsoinhibitscyclicGMP(IC50=2.9μM).Displayshypertensiveproperties.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN(omega)-Monomethyl-L-ArginineAcetate
- MolecularWeight248.28
- Chemicalstructure
![L-NMMA [53308-83-1]](images/hellobio/201710/hb1353.png "L-NMMA [53308-83-1]")
- MolecularFormulaC7H16N4O2.CH3CO2H
- CASNumber53308-83-1
- PubChemidentifier135242
- SMILESCC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N
- InChiInChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
- InChiKeyIKPNWIGTWUZCKM-JEDNCBNOSA-N
- MDLnumberMFCD00069311
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforL-NMMA
Characterizationofthreeinhibitorsofendothelialnitricoxidesynthaseinvitroandinvivo.
ReesDDetal(1990)BrJPharmacol101(3):746-52.PubMedID:1706208Nitricoxidesynthases:structure,functionandinhibition.
AldertonWKetal(2001)BiochemJ357(Pt3):593-615.PubMedID:11463332L-NMMA(anitricoxidesynthaseinhibitor)iseffectiveinthetreatmentofcardiogenicshock.
CotterGetal(2000)Circulation101(12):1358-61.PubMedID:10736276EvidenceforthepathophysiologicalroleofendogenousmethylargininesinregulationofendothelialNOproductionandvascularfunction.
CardounelAJetal(2007)JBiolChem282(2):879-87.PubMedID:17082183
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
