Hello Bio/Nifedipine/HB1228/100mg
商品编号：
HB1228-100mg
品牌：
hellobio
市场价：
¥624.00
美元价：
480.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNifedipine
- ShortdescriptionL-typeCa2+channelblocker
- BIOLOGicaldescriptionL-typeCa2+channelblocker.CausesdownregulationofNF-κB,proinflammatorycytokinesandcelladhesionmolecules.Reducesoxidativestressandsmoothmusclecellproliferationandshowspotentialactionsagainstatherosclerosis.Showsneuroprotectiveactionsfordopaminergicneuronesandactsasavasodilator.
- BiologicalactionBlocker
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester
- MolecularWeight346.34
- Chemicalstructure
![Nifedipine [21829-25-4]](images/hellobio/201710/hb1228.png "Nifedipine [21829-25-4]")
- MolecularFormulaC17H18N2O6
- CASNumber21829-25-4
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNifedipine
Nifedipineandnimodipineprotectdopaminergicsubstantianigraneuronsagainstaxotomy-inducedcelldeathinratvibrosectionsviamodulatinginflammatoryresponses.
DaschilNetal(2014)BrainRes1581:1-11.PubMedID:25038562NifedipineinhibitshypoxiainducedtransvascularleakagethroughdownregulationofNFkB.
SKSSetal(2012)RespirPhysiolNeurobiol183(1):26-34.PubMedID:22627105NifedipineinhibitsvascularsmoothmusclecellproliferationandreactiveoxygenspeciesproductionthroughAMP-activatedproteinkinasesignalingpathway.
SungJYetal(2012)VasculPharmacol56(1-2):1-8.PubMedID:21708289
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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