Hello Bio/Niclosamide/HB1435/25g
商品编号：
HB1435-25g
品牌：
hellobio
市场价：
¥468.00
美元价：
360.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNiclosamide
- ShortdescriptionSTAT3signalingpathwayinhibitor.AntineoplasticagainstAMLstemcells.
- BIOLOGicaldescriptionSTAT3signalingpathwayinhibitorandalsoinhibitsmTORCandWnt/β-cateninpathways.AntineoplasticagainstAMLstemcells.Showsantiproliferative,anticancer,antidiabeticandanthelminticactions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
- MolecularWeight325.99
- Chemicalstructure
![Niclosamide | [50-65-7]](images/hellobio/201710/hb1435.png "Niclosamide | [50-65-7]")
- MolecularFormulaC13H8Cl2N2O4
- CASNumber50-65-7
- PubChemidentifier4477
- SMILESC1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
- InChiInChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
- InChiKeyRJMUSRYZPJIFPJ-UHFFFAOYSA-N
- MDLnumberMFCD00057597
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinDMSO(10mM)andinethanol(10mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNiclosamide
IdentificationofNiclosamideasaNewSmall-MoleculeInhibitoroftheSTAT3SignalingPathway.
RenXetal(2010)ACSMedChemLett1(9):454-9.PubMedID:24900231Niclosamideethanolamine-inducedmildmitochondrialuncouplingimprovesdiabeticsymptomsinmice.
TaoHetal(2014)NatMed20(11):1263-9.PubMedID:25282357ScreenforchemicalmodulatorsofautophagyrevealsnoveltherapeuticinhibitorsofmTORC1signaling.
BalgiADetal(2009)PLoSOne4(9):e7124.PubMedID:19771169
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
