Hello Bio/Naspm trihydrochloride/HB0441/
市场价：
¥1384.50
美元价：
1065.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameNaspm trihydrochloride
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Short descriptionSelective GluA2- lacking, Ca2+ permeable AMPA / kainate receptor antagonist
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Biological descriptionSelective GluA2- lacking, Ca2+ permeable AMPA/kainate receptor antagonist. Synthetic analogue of Joro spider toxin. Reduces excitatory post synaptic currents in infralimbic neurons.
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Biological actionAntagonist
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Purity>97%
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Properties
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Chemical nameN-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
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Molecular Weight479.91
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Chemical structure
![Naspm trihydrochloride [1049731-36-3]](images/hellobio/201710/hb0441.png "Naspm trihydrochloride [1049731-36-3]")
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Molecular FormulaC22H34N4O.3HCl
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CAS Number1049731-36-3
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PubChem identifier16219727
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SMILESC1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN.Cl.Cl.Cl
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InChiInChI=1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
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InChiKeyJNEOJAUJWOPWJS-UHFFFAOYSA-N
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MDL numberMFCD01321052
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewSoluble in water (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Naspm trihydrochloride
Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.
Koike M et al (1997) Neurosci Res 29(1) : 27-36.PubMedID: 9293490ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.
Park K et al (2014) PLoS One 9(6) : e100108.PubMedID: 24925360Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.
Sepulveda-Orengo MT et al (2013) J Neurosci 33(17) : 7184-93.PubMedID: 23616528
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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