Hello Bio/N-Arachidonylglycine (NAGly)/HB0439/
市场价：
¥799.50
美元价：
615.00
产品分类：
酸碱缓冲液
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3392242852
电话号码：
4000-520-616
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商品介绍
Product overview
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NameN-Arachidonylglycine (NAGly)
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Short descriptionEndogenous GLYT2 inhibitor / Cav3.1 / 3.2 / 3.3 current inhibitor
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Biological descriptionEndogenous GLYT2 inhibitor (IC50 = 3 µM) that displays little activity at GLYT1. Also reversibly inhibits Cav3.1, Cav3.2 and Cav3.3 currents (EC50 values are 1.3 µM, 600 nM and 1.6 µM respectively). Novel insulin secretagogue and natural ligand for orphan G-protein-coupled receptor, GPR18. Displays analgesic properties.
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Biological actionInhibitor
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Properties
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Chemical nameN-(1-oxo-5Z,8Z,11Z,14Z-eicosatetrae nyl)glycine
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Molecular Weight361.52
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Chemical structure
![N-Arachidonylglycine (NAGly) [179113-91-8]](images/hellobio/201710/hb0439.png "N-Arachidonylglycine (NAGly) [179113-91-8]")
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Molecular FormulaC22H35NO3
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CAS Number179113-91-8
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PubChem identifier5283389
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SMILESO=C(CCC/C=CC/C=CC/C=CC/C=CCCCCC)NCC(=O)O
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewsoluble in ethanol (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for N-Arachidonylglycine (NAGly)
Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
Ikeda Y et al (2005) Biochem Biophys Res Commun 333(3) : 778-86.PubMedID: 15967412Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.
Kohno M et al (2006) Biochem Biophys Res Commun 347(3) : 827-32.PubMedID: 16844083T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.
Barbara G et al (2009) J Neurosci 29(42) : 13106-14.PubMedID: 19846698Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
Edington AR et al (2009) J Biol Chem 284(52) : 36424-30.PubMedID: 19875446
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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