Hello Bio/N-Arachidonylglycine (NAGly)/HB0439/5mg
商品编号：
HB0439-5mg
品牌：
hellobio
市场价：
¥1267.50
美元价：
975.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameN-Arachidonylglycine(NAGly)
- ShortdescriptionEndogenousGLYT2inhibitor/Cav3.1/3.2/3.3currentinhibitor
- BIOLOGicaldescriptionEndogenousGLYT2inhibitor(IC50=3µM)thatdisplayslittleactivityatGLYT1.AlsoreversIBLyinhibitsCav3.1,Cav3.2andCav3.3currents(EC50valuesare1.3µM,600nMand1.6µMrespectively).NovelinsulinsecretagogueandnaturalligandfororphanG-protein-coupledreceptor,GPR18.Displaysanalgesicproperties.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine
- MolecularWeight361.52
- Chemicalstructure
![N-Arachidonylglycine (NAGly) [179113-91-8]](images/hellobio/201710/hb0439.png "N-Arachidonylglycine (NAGly) [179113-91-8]")
- MolecularFormulaC22H35NO3
- CASNumber179113-91-8
- PubChemidentifier5283389
- SMILESO=C(CCC/C=CC/C=CC/C=CC/C=CCCCCC)NCC(=O)O
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- Solubilityoverviewsolubleinethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforN-Arachidonylglycine(NAGly)
IdentificationofN-arachidonylglycine,U18666A,and4-androstene-3,17-dioneasnovelinsulinSecretagogues.
IkedaYetal(2005)BiochemBiophysResCommun333(3):778-86.PubMedID:15967412IdentificationofN-arachidonylglycineastheendogenousligandfororphanG-protein-coupledreceptorGPR18.
KohnoMetal(2006)BiochemBiophysResCommun347(3):827-32.PubMedID:16844083T-typecalciumchannelinhibitionunderliestheanalgesiceffectsoftheendogenouslipoaminoacids.
BarbaraGetal(2009)JNeurosci29(42):13106-14.PubMedID:19846698Extracellularloops2and4ofGLYT2arerequiredforN-arachidonylglycineinhibitionofglycinetransport.
EdingtonARetal(2009)JBiolChem284(52):36424-30.PubMedID:19875446
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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