Hello Bio/1-Naphthyl PP1/HB0066/50mg
商品编号：
HB0066-50mg
品牌：
hellobio
市场价：
¥10296.00
美元价：
7920.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name1-NaphthylPP1
- ShortdescriptionPotent,selectivesrcfamilykinaseinhibitor
- BIOLOGicaldescriptionPotentandselectivesrcfamilykinaseinhibitor,includingv-Srcandc-Fyn.Selectiveforanalogsratherthanwild-typekinase(IC50valuesare1.5nMand1µMforv-Srcanalogversuswild-type).Alsoinhibitsc-ABIandAuroraAkinaseandisapotentPKDinhibitor.Showsanti-canceractions.Cell-permeable.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- MolecularWeight317.39
- Chemicalstructure
![1-Naphthyl PP1 [221243-82-9]](images/hellobio/201710/hb0066.png "1-Naphthyl PP1 [221243-82-9]")
- MolecularFormulaC19H19N5
- CASNumber221243-82-9
- PubChemidentifier4877
- SMILESCC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(20mg/ml)orchloroform
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor1-NaphthylPP1
Achemicalswitchforinhibitor-sensitiveallelesofanyproteinkinase.
BishopACetal(2000)Nature407(6802):395-401.PubMedID:11014197Newpyrazolopyrimidineinhibitorsofproteinkinasedaspotentanticanceragentsforprostatecancercells.
TandonMetal(2013)PLoSOne8(9):e75601.PubMedID:24086585AuroraAisinvolvedincentralspindleassemblythroughphosphorylationofSer19inP150Glued.
ReboutierDetal(2013)JCellBiol201(1):65-79.PubMedID:23547029
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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