Hello Bio/1-Naphthyl PP1/HB0066/10mg
商品编号：
HB0066-10mg
品牌：
hellobio
市场价：
¥2574.00
美元价：
1980.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name1-Naphthyl PP1
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Short descriptionPotent, selective src family kinase inhibitor
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Biological descriptionPotent and selective src family kinase inhibitor, including v-Src and c-Fyn. Selective for analogs rather than wild-type kinase (IC50 values are 1.5 nM and 1 µM for v-Src analog versus wild-type). Also inhibits c-AbI and Aurora A kinase and is a potent PKD inhibitor. Shows anti-cancer actions. Cell-permeable.
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Molecular Weight317.39
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Chemical structure
![1-Naphthyl PP1 [221243-82-9]](images/hellobio/201710/hb0066.png "1-Naphthyl PP1 [221243-82-9]")
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Molecular FormulaC19H19N5
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CAS Number221243-82-9
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PubChem identifier4877
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SMILESCC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in DMSO (20mg/ml) or chloroform
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for 1-Naphthyl PP1
A chemical switch for inhibitor-sensitive alleles of any protein kinase.
Bishop AC et al (2000) Nature 407(6802) : 395-401.PubMedID: 11014197New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells.
Tandon M et al (2013) PLoS One 8(9) : e75601.PubMedID: 24086585Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.
Reboutier D et al (2013) J Cell Biol 201(1) : 65-79.PubMedID: 23547029
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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