Hello Bio/Naloxone hydrochloride/HB2451/
市场价：
¥565.50
美元价：
435.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNaloxonehydrochloride
- ShortdescriptionCompetitiveopioidreceptorantagoNIST
- BIOLOGicaldescription
Competitiveopioidreceptorantagonistwithhighaffinityatµ-opioidreceptors.Blockseffectsofopiods.Inducesacutewithdrawalstateinopiate-dependentmodels.
Activeinvivo.
- AlternativenamesNLX
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-onehydrochloride
- MolecularWeight363.84
- Chemicalstructure
- MolecularFormulaC19H21NO4.HCl
- CASNumber357-08-4
- PubChemidentifier5464092
- SMILESC=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
- InChiInChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h4-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
- InChiKeyRGPDIGOSVORSAK-STHHAXOLSA-N
- MDLnumberMFCD00150901
- AppearanceWhitesolid
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNaloxonehydrochloride
Naloxoneactivationofmu-opioidreceptorsmutatedatahistidineresidueliningtheopioidbindingcavity.
Spivaketal(1997)MolPharmacol52(6):983-92PubMedID:9415708Errorcorrectioninlatentinhibitionanditsdisruptionbyopioidreceptorblockadewithnaloxone.
Leungetal(2013)Neuropsychopharmacology38(12):2439-45PubMedID:23748224Quantitativeevaluationofopioidwithdrawalsignsinratsrepeatedlytreatedwithmorphineandinjectedwithnaloxone,intheabsenceorpresenceoftheantiabstinenceagentclonidine.
Pinellietal(1997)JPharmacolToxicolMethods38(3):117-31PubMedID:9523765
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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