Productoverview

• Name
  MTEPhydrochloride
• Shortdescription
  Potent,highlyselective,non-competitivemGluR₅antagoNIST
• BIOLOGicaldescription

  Potent,highlyselectiveandnon-competitivemGlu₅receptorantagonist(IC₅₀=5nMandK_i=16nMinaninvitroCa²⁺-fluxassay).

  HasnosignificanteffectonothermGluRsandshowsfeweroff-targeteffectsthan MPEPhydrochloride. Shows~10-foldgreaterseletivityformGlu₅thanMPEP.

  BlocksinductionoftLTP(timing-dependentlongtermpotentiation)andhasantidepressant,anxiolyticandneuroprotectiveproperties.Activeinvivo.

• Biologicalaction
  Antagonist
• Purity
  >98%
• Ourproductsinaction
  SubmitYourCitationNow

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Properties

• Chemicalname
  3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridinehydrochloride
• MolecularWeight
  236.72
• Chemicalstructure
  
• MolecularFormula
  C₁₁H₈N₂S.HCl
• CASNumber
  1186195-60-7
• PubChemidentifier
  45073467
• SMILES
  CC1=NC(=CS1)C#CC2=CN=CC=C2.Cl
• Source
  Synthetic
• InChi
  InChI=1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h4-3,6-8H,1H3;1H
• InChiKey
  YCIOJDKGCWAHLR-UHFFFAOYSA-N
• MDLnumber
  MFCD08458895
• Appearance
  Lightcreamsolid

StoringandUsingYourProduct

• Storageinstructions
  +4°C(desiccate)
• Solubilityoverview
  Solubleinwater(100mM)andinDMSO(100mM)
• Important
  ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforMTEPhydrochloride

• NeuroprotectivepotentialofmGluR5antagonistMTEP:effectsonkainate-inducedexcitotoxicityintherathippocampus.

  DominHetal(2010)PharmacolRep62(6):1051-61.

  PubMedID:21273662

• NMDAbutnotAMPAglutamatergicreceptorsareinvolvedintheantidepressant-likeactivityofMTEPduringtheforcedswimtestinmice.

  Pomierny-ChamiołoLetal(2010)PharmacolRep62(6):1186-90.

  PubMedID:21273676

• Metabotropicglutamatereceptor5negativeallostericmodulatorsasnoveltoolsforinvivoinvestigation.

  KeckTMetal(2012)ACSMedChemLett3(7):544-549.

  PubMedID:22924094

• Metabotropicglutamatereceptorsubtype5antagonistsMPEPandMTEP.

  LeaandFaden(2006)CNSDrugRev.12(2):149-66

  PubMedID:16958988

• GatingofNMDAreceptor-mediatedhippocampalspiketiming-dependentpotentiationbymGluR5.

  KwagandPaulsen(2012)Neuropharmacology63(4):701-9

  PubMedID:22652057
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.