Hello Bio/MS 436/HB1450/5mg
商品编号：
HB1450-5mg
品牌：
hellobio
市场价：
¥1306.50
美元价：
1005.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameMS436
- ShortdescriptionPotent,selectiveBRD4bromodomaininhibitor
- BIOLOGicaldescriptionPotentandselectiveBRD4bromodomaininhibitor(Ki=30-50nM).Selectiveforthefirstoverthesecondbromodomain.InhibitstheactivityofBRD4inmacrophagenitricoxideandIl-6production.Alterscolonyintegrityinembryonicstemcells.Showsantiproliferativeandanticanceractions.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
- MolecularWeight383.42
- Chemicalstructure
![MS 436 [1395084-25-9]](images/hellobio/201710/hb1450.png "MS 436 [1395084-25-9]")
- MolecularFormulaC18H17N5O3S
- CASNumber1395084-25-9
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforMS436
BRD4sustainsmelanomaproliferationandrepresentsanewtargetforepigenetictherapy.
SeguraMFetal(2013)CancerRes73(20):6264-76.PubMedID:23950209Structure-guideddesignofpotentdiazobenzeneinhibitorsfortheBETbromodomains.
ZhangGetal(2013)JMedChem56(22):9251-64.PubMedID:24144283ControlofembryonicstemcellidentitybyBRD4-dependenttranscriptionalelongationofsuper-enhancer-associatedpluripotencygenes.
DiMiccoRetal(2014)CellRep9(1):234-47.PubMedID:25263550
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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