Hello Bio/MPEP hydrochloride/HB0426/50mg
商品编号:
HB0426-50mg
品牌:
hellobio
市场价:
¥3880.50
美元价:
2985.00
产品分类:
酸碱缓冲液
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product overview
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NameMPEP hydrochloride
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Short descriptionPotent, selective mGlu5 antagonist / mGlu4 positive allosteric modulator
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Biological description
Potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 36 nM). Also a mGlu4 receptor positive allosteric modulator.
Prevents induction of various types of long term potentiation (LTP) and long term depression (LTD).
Suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. Blood-brain barrier permeable. Active in vivo.
Water soluble MTEP hydrochloride also available.
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Biological actionAntagonist
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Purity>98%
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Our products in action1 citation Submit Your Citation Now
Images
Properties
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Chemical name2-Methyl-6-(phenylethynyl)pyridine hydrochloride
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Molecular Weight229.71
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Chemical structure
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Molecular FormulaC14H11N.HCl
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CAS Number219911-35-0
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PubChem identifier9794588
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SMILESCC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl
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SourceSynthetic
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InChiInChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h4-9H,1H3;1H
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InChiKeyPKDHDJBNEKXCBI-UHFFFAOYSA-N
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MDL numberMFCD02262119
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AppearanceWhite solid
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewSoluble in DMSO (100mM) and in ethanol (100 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for MPEP hydrochloride
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
Gasparini F et al (1999) Neuropharmacology 38(10) : 1493-503.PubMedID: 10530811Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.
Latif-Hernandez et al (2016) Front Cell Neurosci. 7; : 10:252PubMedID: 27872582NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.
Izumi and Zorumski (2012) Neuropsychopharmacology 37(3) : 609-17PubMedID: 21993209Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.
Mihov and Hasler (2016) Int J Neuropsychopharmacol. 5; : 19(7)PubMedID: 26802568
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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