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商品详细Hello Bio/MPEP hydrochloride/HB0426/50mg
Hello Bio/MPEP hydrochloride/HB0426/50mg
Hello Bio/MPEP hydrochloride/HB0426/50mg
商品编号: HB0426-50mg
品牌: hellobio
市场价: ¥3880.50
美元价: 2985.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Product overview

  • Name
    MPEP hydrochloride
  • Short description
    Potent, selective mGlu5 antagonist / mGlu4 positive allosteric modulator
  • Biological description

    Potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 36 nM). Also a mGlu4 receptor positive allosteric modulator.

    Prevents induction of various types of long term potentiation (LTP) and long term depression (LTD).

    Suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. Blood-brain barrier permeable. Active in vivo.

    Water soluble MTEP hydrochloride also available.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action
    1 citation Submit Your Citation Now

Images

Properties

  • Chemical name
    2-Methyl-6-(phenylethynyl)pyridine hydrochloride
  • Molecular Weight
    229.71
  • Chemical structure
    MPEP hydrochloride  [219911-35-0]
  • Molecular Formula
    C14H11N.HCl
  • CAS Number
    219911-35-0
  • PubChem identifier
    9794588
  • SMILES
    CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h4-9H,1H3;1H
  • InChiKey
    PKDHDJBNEKXCBI-UHFFFAOYSA-N
  • MDL number
    MFCD02262119
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MPEP hydrochloride

  • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.

    Gasparini F et al (1999) Neuropharmacology 38(10) : 1493-503.
    PubMedID: 10530811
  • Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.

    Latif-Hernandez et al (2016) Front Cell Neurosci. 7; : 10:252
    PubMedID: 27872582
  • NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.

    Izumi and Zorumski (2012) Neuropsychopharmacology 37(3) : 609-17
    PubMedID: 21993209
  • Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.

    Mihov and Hasler (2016) Int J Neuropsychopharmacol. 5; : 19(7)
    PubMedID: 26802568
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.