Hello Bio/MPEP hydrochloride/HB0426/10mg-免疫在线蚂蚁淘旗下平台

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商品详细Hello Bio/MPEP hydrochloride/HB0426/10mg

Hello Bio/MPEP hydrochloride/HB0426/10mg

商品编号： HB0426-10mg

品牌： hellobio

市场价： ¥1170.00

美元价： 900.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Productoverview

Name
MPEPhydrochloride
Shortdescription
Potent,selectivemGlu₅antagoNIST/mGlu₄positiveallostericmodulator
BIOLOGicaldescription
Potent,selectiveandnon-competitivemGlu₅receptorantagonist(IC₅₀=36nM).AlsoamGlu₄receptorpositiveallostericmodulator.
Preventsinductionofvarioustypesoflongtermpotentiation(LTP)andlongtermdepression(LTD).
Suppressesaddiction-likebehaviourforcocaine,ethanolandnicotineinvariousmodelsofaddiction.Blood-brainbarrierpermeable.Activeinvivo.
Watersoluble MTEPhydrochloridealsoavailable.
Biologicalaction
Antagonist
Purity
>98%
Ourproductsinaction
1citationSubmitYourCitationNow

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Properties

Chemicalname
2-Methyl-6-(phenylethynyl)pyridinehydrochloride
MolecularWeight
229.71
Chemicalstructure
MolecularFormula
C₁₄H₁₁N.HCl
CASNumber
219911-35-0
PubChemidentifier
9794588
SMILES
CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl
Source
Synthetic
InChi
InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h4-9H,1H3;1H
InChiKey
PKDHDJBNEKXCBI-UHFFFAOYSA-N
MDLnumber
MFCD02262119
Appearance
Whitesolid

StoringandUsingYourProduct

Storageinstructions
+4°C(desiccate)
Solubilityoverview
SolubleinDMSO(100mM)andinethanol(100mM)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforMPEPhydrochloride

2-Methyl-6-(phenylethynyl)-pyridine(MPEP),apotent,selectiveandsystemicallyactivemGlu5receptorantagonist.
GaspariniFetal(1999)Neuropharmacology38(10):1493-503.
PubMedID:10530811
SeparateIonotropicandMetabotropicGlutamateReceptorFunctionsinDepotentiationvs.LTP:ADistinctRoleforGroup1mGluRSubtypesandNMDARs.
Latif-Hernandezetal(2016)FrontCellNeurosci.7;:10:252
PubMedID:27872582
NMDAreceptors,mGluR5,andendocannABInoidsareinvolvedinacascadeleADIngtohippocampallong-termdepression.
IzumiandZorumski(2012)Neuropsychopharmacology37(3):609-17
PubMedID:21993209
NegativeAllostericModulatorsofMetabotropicGlutamateReceptorsSubtype5inAddiction:aTherapeuticWindow.
MihovandHasler(2016)IntJNeuropsychopharmacol.5;:19(7)
PubMedID:26802568

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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