Hello Bio/ML-7 hydrochloride/HB0415/25mg
商品编号：
HB0415-25mg
品牌：
hellobio
市场价：
¥2730.00
美元价：
2100.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameML-7hydrochloride
- ShortdescriptionSelectiveMLCKinhibitor
- BIOLOGicaldescriptionSelectivemyosinlightchainkinase(MLCK)inhibitor(Ki=0.3µM).ShowsreversIBLeATP-competitiveinhibitionofCa2+calmodulinindependent/dependantsmoothmuscleMLCK.Approx10-foldmorepotentinhibitorthanML-9Showsantiglaucomatousactions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameHexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepinehydrochloride
- MolecularWeight452.74
- Chemicalstructure
![ML-7 [110448-33-4]](images/hellobio/201710/hb0415_1.png "ML-7 [110448-33-4]")
- MolecularFormulaC15H17IN2O2S.HCl
- CASNumber110448-33-4
- PubChemidentifier9803932
- SMILESC1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- SolubilityoverviewsolubleinDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforML-7hydrochloride
Selectiveinhibitionofcatalyticactivityofsmoothmusclemyosinlightchainkinase.
SaitohMetal(1987)JBiolChem262(16):7796-801.PubMedID:3108259Thespecificitiesofproteinkinaseinhibitors:anupdate.
BainJetal(2003)BiochemJ371(Pt1):199-204.PubMedID:12534346EffectsofML-7andY-27632oncarbachol-andendothelin-1-inducedcontractionofbovinetrabecularmeshwork.
RosenthalRetal(2005)ExpEyeRes80(6):837-45.PubMedID:15939040
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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