Hello Bio/(+)-MK 801 maleate/HB0004/50mg-免疫在线蚂蚁淘旗下平台

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商品详细Hello Bio/(+)-MK 801 maleate/HB0004/50mg

Hello Bio/(+)-MK 801 maleate/HB0004/50mg

商品编号： HB0004-50mg

品牌： hellobio

市场价： ¥2457.00

美元价： 1890.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Productoverview

Name
(+)-MK801maleate
Shortdescription
Potent,selective,non-competitiveNMDAreceptorantagoNIST
BIOLOGicaldescription
Potent,selectiveandnon-competitiveNMDAreceptorantagonist(K_d=37.2nM).Approx10-foldmorepotentthan(-)-MK801maleate.Preventscalciumioninfluxandlongtermpotentiationinduction.Showsanticonvulsantandneuroprotectiveproperties.
Alternativenames
Dizocilpinemaleate,Dizocilpine
Biologicalaction
Antagonist
Purity
>98%
Ourproductsinaction
1citationSubmitYourCitationNow

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Properties

Chemicalname
(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-iminemaleate
MolecularWeight
337.37
Chemicalstructure
MolecularFormula
C₁₆H₁₅N.C₄H₄O₄
CASNumber
77086-22-7
PubChemidentifier
6420042
SMILES
C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O
Source
Synthetic
InChi
InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h4-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
InChiKey
QLTXKCWMEZIHBJ-PJGJYSAQSA-N
MDLnumber
MFCD00082465
Appearance
Whitesolid

Applications

Applicationnotes
TheNMDAreceptorantagonist(+)-MK801isuse-dependentandblocksNMDARsintheiropenconformation.
(+)-MK801fromHelloBiofullyabolishesevokedNMDARcurrentsat10μMrapidlyuponrepeatedstimulations(seeFig1above).Atconcentrationsof50μMamorerapidreceptorblockadewasobserved.

#Protocol1:EvokedNMDAreceptorcurrents
- WholecellvoltageclamprecordingswereobtainedfromlayerVneuronsofthemouseprelimbiccortexbrainslice.
- NMDAcurrentswereevokedviaastimulatingelectrodeplacedinlayersII/IIIandevokedbyasinglesquare(150μs)pulseevery10secatastimulusintensitythatgaveareliableNMDAcurrent.
- Neuronswereheldat+40mVtorelieveNMDAcurrentsfromtheirvoltage-dependentMg²⁺block.
- NMDAcurrentswerecontinuallystimulatedandrecordedinresponsetocontinualbathapplicationsof(+)-MK801untilNMDAcurrentswerecompletelyabolished.
- AllNMDARrecordingsweremadeinthepresenceofGABA_A-RandAMPARantagonists.

StoringandUsingYourProduct

Storageinstructions
Roomtemperature
Solubilityoverview
Solubleinwater(25mM,gentlewarming)andinDMSO(100mM)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

Referencesfor(+)-MK801maleate

EffectsofMK-801stereoisomersonschedule-controlledbehaviorinrats.
GenoveseRFetal(1991)Psychopharmacology(Berl)105(4):477-80.
PubMedID:1771215
Theeffectsofdizocilpinemaleate(MK-801),anantagonistoftheN-methyl-D-aspartatereceptor,onneurologicrecoveryandhistopathologyfollowingcompletecerebralischemiainprimates.
LanierWLetal(1990)JCerebBloodFlowMetab10(2):252-61.
PubMedID:2154509
MK-801blocksNMDAreceptor-mediatedsynaptictransmissionandlongtermpotentiationinrathippocampalslices.
CoanEJetal(1987)NeurosciLett80(1):111-4.
PubMedID:2821457
TheanticonvulsantMK-801isapotentN-methyl-D-aspartateantagonist.
WongEHetal(1986)ProcNatlAcadSciUSA83(18):7104-8.
PubMedID:3529096

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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