Hello Bio/MG132/HB4135/25mg
商品编号：
HB4135-5mg
品牌：
hellobio
市场价：
¥1053.00
美元价：
810.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameMG132
- ShortdescriptionPotent,cell-permeableproteasomeinhibitor.Calpaininhibitor.
- BIOLOGicaldescriptionPotent,cell-permeableproteasomeinhibitor(IC50=100nM).Blockstheproteolyticactivityofthe26Sproteasomecomplex.Inducescellcyclearrestandtriggersapoptosistoinhibitcellgrowth.Showsanti-canceractivityinvivo.Alsocalpaininhibitor.
- AlternativenamesZ-LLL-al,Z-Leu-Leu-Leu-CHO
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
- MolecularWeight475.62
- Chemicalstructure
![MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ]](images/hellobio/201710/hb4135_1.png "MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ]")
- MolecularFormulaC26H41N3O5
- CASNumber133407-82-6
- PubChemidentifier462382
- SMILESCC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
- SourceSynthetic
- InChiInChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
- InChiKeyTZYWCYJVHRLUCT-VABKMULXSA-N
- MDLnumberMFCD00674886
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforMG132
TheeffectofMG132,aproteasomeinhibitoronHeLacellsinrelationtocellgrowth,reactiveoxygenspeciesandGSH.
Hanetal(2009)OncolRep22(1):215-21PubMedID:19513526PotentialoftheproteasomalinhibitorMG-132asananticanceragent,aloneandincombination.
BanerjeetandLiefshitz(2001)AnticancerRes3941-7:21(6A)PubMedID:11911275Differentialinhibitionofcalpainandproteasomeactivitiesbypeptidylaldehydesofdi-leucineandtri-leucine.
Tsubukietal(1996)JBiochem119(3):572-6PubMedID:8830056
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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