Hello Bio/MG132/HB4135/5mg
商品编号：
HB4135-5mg
品牌：
hellobio
市场价：
¥1053.00
美元价：
810.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameMG132
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Short descriptionPotent, cell-permeable proteasome inhibitor. Calpain inhibitor.
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Biological descriptionPotent, cell-permeable proteasome inhibitor (IC50 = 100 nM). Blocks the proteolytic activity of the 26S proteasome complex. Induces cell cycle arrest and triggers apoptosis to inhibit cell growth. Shows anti-cancer activity in vivo. Also calpain inhibitor.
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Alternative namesZ-LLL-al, Z-Leu-Leu-Leu-CHO
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameN-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
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Molecular Weight475.62
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Chemical structure
![MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ]](images/hellobio/201710/hb4135_1.png "MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ]")
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Molecular FormulaC26H41N3O5
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CAS Number133407-82-6
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PubChem identifier462382
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SMILESCC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
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SourceSynthetic
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InChiInChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
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InChiKeyTZYWCYJVHRLUCT-VABKMULXSA-N
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MDL numberMFCD00674886
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewSoluble in DMSO (100mM) and in ethanol (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for MG132
The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.
Han et al (2009) Oncol Rep 22(1) : 215-21PubMedID: 19513526Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination.
Banerjeet and Liefshitz (2001) Anticancer Res 3941-7 : 21(6A)PubMedID: 11911275Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine.
Tsubuki et al (1996) J Biochem 119(3) : 572-6PubMedID: 8830056
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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