Hello Bio/Memantine hydrochloride/HB0407/100mg
商品编号：
HB0407-100mg
品牌：
hellobio
市场价：
¥1950.00
美元价：
1500.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameMemantine hydrochloride
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Short descriptionNon-competitive NMDA receptor antagonist
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Biological description
Non-competitive NMDA receptor antagonist (IC50 = 1.25 μM). Binds to ion channel site.
Shows low affinity but has rapid blocking and unblocking ability at the NMDAR.
Selectively blocks extrasynaptic NMDARs.
Enhances hippocampal long-term potentiation (LTP) and reverses LTP suppression.
Improves cognitive function and shows anti-Alzheimer's activity.
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Alternative namesAxura, Akatinol, Namenda, Ebixa, Abixa, Memox
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Biological actionAntagonist
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Purity>98%
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Images
Properties
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Chemical name3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
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Molecular Weight215.77
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Chemical structure
![Memantine hydrochloride [41100-52-1]](images/hellobio/201710/hb0407.png "Memantine hydrochloride [41100-52-1]")
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Molecular FormulaC12H21N.HCl
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CAS Number41100-52-1
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PubChem identifier181458
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SMILESCl.CC13CC2(C)CC(N)(C1)CC(C2)C3
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InChiInChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
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InChiKeyLDDHMLJTFXJGPI-UHFFFAOYSA-N
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MDL numberMFCD00214336
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AppearanceWhite solid
Applications
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Application notes
The voltage sensitive NMDA receptor antagonist memantine is effective at concentrations of 10-100 µM. In CA1 hippocampal neurons held at – 30 Mv, Hello Bio memantine (at 100 µM) gradually inhibited evoked NMDA receptor mediated excitatory currents over time (see Fig 1 above).
#Protocol 1: Assay evoked NMDAR currents at -30 mV (used for memantine)
- NMDAR currents were recorded via whole cell voltage clamp recordings of CA1 pyramidal neurons from the rat hippocampal brain slice and evoked via a stimulating electrode placed in the CA3 region to stimulate the Schaffer collateral pathway.
- Each NMDAR current was evoked via a single square (150 µs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDAR current.
- Neurons were constantly held at -30 mV and NMDAR currents recorded in response to continual bath applications of NMDAR antagonists.
- All NMDAR recordings were made in the presence of GABAA-R and AMPA-R antagonists.
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in water (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Memantine hydrochloride
The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner.
Rammes G et al (2001) Neurosci Lett 306(1-2) : 81-4.PubMedID: 11403963Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data.
Parsons CG et al (1999) Neuropharmacology 38(6) : 735-67.PubMedID: 10465680Memantine binding to a superficial site on NMDA receptors contributes to partial trapping.
Kotermanski SE et al (2009) J Physiol 587(Pt 19) : 4589-604.PubMedID: 19687120Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons.
Wu and Johnson (2015) Brain Res. 1603 : 1-7PubMedID: 25656790Effects of memantine on hippocampal long-term potentiation, gamma activity, and sensorimotor gating in freely moving rats.
Ma et al (2015) Neurobiol Aging 36(9) : 2544-54PubMedID: 26119223
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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