Hello Bio/MC 1568/HB1390/25mg
商品编号：
HB1390-25mg
品牌：
hellobio
市场价：
¥5518.50
美元价：
4245.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameMC1568
- ShortdescriptionSelectiveclassIIaHDACinhibitor
- BIOLOGicaldescriptionSelectiveclassIIahistonedeacetylase(HDAC)inhibitor.InhibitsHDAC4andHDAC5intheheartandskeletalmuscleandsuppressesmyogenesis.AlsoinhibitsIL-8expressionandpromotesneuritegrowth.Showsneuroprotective,anti-proliferativeandanti-canceractions.Blood-brainbarrierpermeable.
- BiologicalactionInhibitor
- Purity>96%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
- MolecularWeight314.31
- Chemicalstructure
![MC 1568 [852475-26-4]](images/hellobio/201710/hb1390.png "MC 1568 [852475-26-4]")
- MolecularFormulaC17H15FN2O3
- CASNumber852475-26-4
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforMC1568
ClassII-specifichistonedeacetylaseinhibitorsMC1568andMC1575suppressIL-8expressioninhumanmelanomacells.
VenzaIetal(2013)PigmentCellMelanomaRes26(2):193-204.PubMedID:23176534Class-IIaHistoneDeacetylaseInhibitionPromotestheGrowthofNeuralProcessesandProtectsThemAgainstNeurotoxicInsult.
CollinsLMetal(2014)MolNeurobiol:PubMedID:25065734SelectiveclassIIHDACinhibitorsimpairmyogenesisbymodulatingthestABIlityandactivityofHDAC-MEF2complexes.
NEBbiosoAetal(2009)EMBORep10(7):776-82.PubMedID:19498465
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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