Hello Bio/Margatoxin/HB1083/100μg
商品编号：
HB1083-100μg
品牌：
hellobio
市场价：
¥4036.50
美元价：
3105.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameMargatoxin
- ShortdescriptionPotent,non-selectiveKv1.3channelblocker
- BIOLOGicaldescriptionPotentandnon-selectiveKv1.3channelblocker(IC50=approx.30pM;Kd=11.7pM).AlsoinhibitsKv1.2andKv1.1channels(Kdvaluesare6.4pMand4.2nMrespectively).BlocksVEGF-inducedCa2+entryandhyperpolarisationofendothelialcells.
- BiologicalactionBlocker
- OurproductsinactionSubmitYourCitationNow
Properties
- MolecularWeight4178.96
- MolecularFormulaC178H286N52O50S7
- CASNumber145808-47-5
StoringandUsingYourProduct
- Storageinstructions-20°C
- Solubilityoverviewsolubleinwater
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforMargatoxin
Margatoxinisanon-selectiveinhibitorofhumanKv1.3K+channels.
BartokAetal(2014)Toxicon87:6-16.PubMedID:24878374Purification,characterization,andbiosynthesisofmargatoxin,acomponentofCentruroidesmargaritatusvenomthatselectivelyinhibitsvoltage-dependentpotassiumchannels.
Garcia-CalvoMetal(1993)JBiolChem268(25):18866-74.PubMedID:8360176MargatoxininhibitsVEGF-inducedhyperpolarization,proliferationandnitricoxideproductionofhumanendothelialcells.
ErdoganAetal(2005)JVascRes42(5):368-76.PubMedID:16043967
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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