Hello Bio/LY367385/HB0398/25mg
商品编号：
HB0398-5mg
品牌：
hellobio
市场价：
¥702.00
美元价：
540.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameLY367385
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Short descriptionPotent, highly selective mGlu1a antagonist
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Biological description
Potent, highly selective and competitive mGlu1a receptor antagonist (IC50 = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR5 mediated responses).
Impairs induction and late phases of both long term potentiation (LTP) and long term depression (LTD) when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS).
Also displays antidepressant, anticonvulsant and neuroprotective actions.
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Biological actionAntagonist
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Purity>98%
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Our products in action2 citations Submit Your Citation Now
Images
Properties
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Chemical name(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
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Molecular Weight209.2
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Chemical structure
![LY 367385 [198419-91-9]](images/hellobio/201710/hb0398.png "LY 367385 [198419-91-9]")
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Molecular FormulaC10H11NO4
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CAS Number198419-91-9
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PubChem identifier5311261
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SMILESCC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N
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SourceSynthetic
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InChiInChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h4-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
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InChiKeySGIKDIUCJAUSRD-QMMMGPOBSA-N
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MDL numberMFCD02262124
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AppearanceOff-white solid
Storing and Using Your Product
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Storage instructionsRoom temperature (desiccate)
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Solubility overviewSoluble in 0.1M NaOH (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for LY367385
Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).
Chapman AG et al (1999) Eur J Pharmacol 368(1) : 17-24.PubMedID: 10096765Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept
Bruno V et al (1999) Neuropharmacology 38(2) : 199-207.PubMedID: 10218860Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.
Car H et al (2006) Pharmacol Rep 58(5) : 758-64.PubMedID: 17085869Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Neyman et al (2008) Eur J Neurosci 27(6) : 1345-52PubMedID: 18364018
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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