Hello Bio/Lomeguatrib/HB1376/25mg
商品编号：
HB1376-25mg
品牌：
hellobio
市场价：
¥3393.00
美元价：
2610.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameLomeguatrib
- ShortdescriptionPotentMGMTinhibitor
- BIOLOGicaldescriptionPotentO6-methylguanine-DNAmethyltransferase(MGMT)inhibitor(IC50=9nM).Actsasapseudosubstrate.Enhancestemozolomideanti-tumoractivity.Showsanti-canceractions.
- AlternativenamesPaTrin-2;Patrin;O6-(4-bromothenyl)guanine;4-BTG
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine
- MolecularWeight326.17
- Chemicalstructure
![Lomeguatrib [192441-08-0]](images/hellobio/201710/hb1376.png "Lomeguatrib [192441-08-0]")
- MolecularFormulaC10H8BrN5OS
- CASNumber192441-08-0
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforLomeguatrib
Monosaccharide-linkedinhibitorsofO(6)-methylguanine-DNAmethyltransferase(MGMT):synthesis,molecularmodeling,andstructure-activityrelationships.
ReinhardJetal(2001)JMedChem44(24):4050-61.PubMedID:11708909O6-(4-bromothenyl)guaninereversestemozolomideresistanceinhumanbreasttumourMCF-7cellsandxenografts.
ClemonsMetal(2005)BrJCancer93(10):1152-6.PubMedID:16278661ThetherapeuticpotentialofO6-alkylguanineDNAalkyltransferaseinhibitors.
KhanOetal(2007)ExpertOpinInvestigDrugs16(10):1573-84.PubMedID:17922622
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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