Hello Bio/Linopirdine dihydrochloride/HB1082/10mg
商品编号：
HB1082-10mg
品牌：
hellobio
市场价：
¥1696.50
美元价：
1305.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameLinopirdinedihydrochloride
- ShortdescriptionKv7channelblocker
- BIOLOGicaldescriptionKv7channelblocker.IncreasesAChreleaseinthebrainandblocksMcurrents(IC50=2.4µM).InducesincreasedneocorticalFosproteinexpressioninagedrats.AlsoagonisesTRPV1(transientreceptorpotentialvanilloidtype1)channel.Showsexcitatoryactionsonnociceptorsandshowscognitionenhancingactions.
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-onedihydrochloride
- MolecularWeight464.39
- Chemicalstructure
![Linopirdine dihydrochloride [113168-57-3]](images/hellobio/201710/hb1082.png "Linopirdine dihydrochloride [113168-57-3]")
- MolecularFormulaC26H21N3O.2HCl
- CASNumber113168-57-3
- PubChemidentifier14209557
- SMILESC1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
- InChiInChI=1S/C26H21N3O.2ClH/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22;;/h1-17H,18-19H2;2*1H
- InChiKeyZEVVHCGTTNRYOY-UHFFFAOYSA-N
- MDLnumberMFCD00867216
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(100mM)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforLinopirdinedihydrochloride
TheM-channelblockerlinopirdineisanagoNISTofthecapsaicinreceptorTRPV1.
NeacsuCetal(2010)JPharmacolSci114(3):332-40.PubMedID:21099148Selectivityoflinopirdine(DuP996),aneurotransmitterreleaseenhancer,inblockingvoltage-dependentandcalcium-activatedpotassiumcurrentsinhippocampalneurons.
SchneeMEetal(1998)JPharmacolExpTher286(2):709-17.PubMedID:9694925TheacetylcholinereleaseenhancerlinopirdineinducesFosinneocortexofagedrats.
DentGWetal(2001)NeurobiolAging22(3):485-94.PubMedID:11378256
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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