Hello Bio/Lestaurtinib/HB1429/5mg
商品编号：
HB1429-5mg
品牌：
hellobio
市场价：
¥10452.00
美元价：
8040.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
-
NameLestaurtinib
-
Short descriptionPotent, non-selective tyrosine kinase inhibitor
-
Biological descriptionPotent and non-selective tyrosine kinase inhibitor. Inhibits JAK2 and JAK3 (IC50 values are 0.9 and 3 nM respectively). Also inhibits TrkA, TrkB, TrkC and FLT3 and prevents phosphorylation of STAT5. Shows anti-proliferative and anti-tumor actions.
-
Alternative namesCEP-701; KT-5555
-
Biological actionInhibitor
-
Purity>99%
-
Our products in actionSubmit Your Citation Now
Properties
-
Chemical name(9S,10S,12R)-2,3,9,10,11,12-Hexahyd ro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epo xy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1, 6]benzodiazocin-1-one
-
Molecular Weight439.46
-
Chemical structure
![Lestaurtinib [111358-88-4]](images/hellobio/201710/hb1429.png "Lestaurtinib [111358-88-4]")
-
Molecular FormulaC26H21N3O4
-
CAS Number111358-88-4
Storing and Using Your Product
-
Storage instructions-20°C (desiccate)
-
Solubility overviewsoluble in DMSO (100mM) or ethanol (25mM)
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Lestaurtinib
Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.
Hexner EO et al (2008) Blood 111(12) : 5663-71.PubMedID: 17984313Effect of FLT3 inhibition on normal hematopoietic progenitor cells.
Weisel KC et al (2007) Ann N Y Acad Sci 1106 : 190-6.PubMedID: 17442779The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness.
Miknyoczki SJ et al (1999) Ann N Y Acad Sci 880 : 252-62.PubMedID: 10415871Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma.
Iyer R et al (2010) Clin Cancer Res 16(5) : 1478-85.PubMedID: 20179224
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
