Hello Bio/Lestaurtinib/HB1429/1mg
商品编号：
HB1429-1mg
品牌：
hellobio
市场价：
¥2632.50
美元价：
2025.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameLestaurtinib
- ShortdescriptionPotent,non-selectivetyrosinekinaseinhibitor
- BIOLOGicaldescriptionPotentandnon-selectivetyrosinekinaseinhibitor.InhibitsJAK2andJAK3(IC50valuesare0.9and3nMrespectively).AlsoinhibitsTrkA,TrkB,TrkCandFLT3andpreventsphosphorylationofSTAT5.Showsanti-proliferativeandanti-tumoractions.
- AlternativenamesCEP-701;KT-5555
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3",2",1"-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
- MolecularWeight439.46
- Chemicalstructure
![Lestaurtinib [111358-88-4]](images/hellobio/201710/hb1429.png "Lestaurtinib [111358-88-4]")
- MolecularFormulaC26H21N3O4
- CASNumber111358-88-4
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforLestaurtinib
Lestaurtinib(CEP701)isaJAK2inhibitorthatsuppressesJAK2/STAT5signalingandtheproliferationofprimaryerythroidcellsfrompatientswithmyeloproliferativedisorders.
HexnerEOetal(2008)Blood111(12):5663-71.PubMedID:17984313EffectofFLT3inhibitiononnormalhematopoieticProgenitorcells.
WeiselKCetal(2007)AnnNYAcadSci1106:190-6.PubMedID:17442779ThenovelTrkreceptortyrosinekinaseinhibitorCEP-701(KT-5555)exhibitsantitumorefficacyagainsthumanpancreaticcarcinoma(Panc1)xenograftgrowthandinvivoinvasiveness.
MiknyoczkiSJetal(1999)AnnNYAcadSci880:252-62.PubMedID:10415871Lestaurtinibenhancestheantitumorefficacyofchemotherapyinmurinexenograftmodelsofneuroblastoma.
IyerRetal(2010)ClinCancerRes16(5):1478-85.PubMedID:20179224
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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