Hello Bio/Lamotrigine/HB0368/
市场价：
¥955.50
美元价：
735.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameLamotrigine
- ShortdescriptionNa2+/K+/Ca2+channelinhibitor.Anticonvulsant.
- BIOLOGicaldescriptionAnticonvulsant.Inhibitsvoltage-dependentNa2+channels,K+andCa2+channels.Inhibitsα4β2-nAChreceptormediatedcurrentsandreducesGABAAreceptortransmission.Inhibits5-HT,noradrenalineanddopamineuptakeintosynaptosomes(IC50valuesare474,239and322µMrespectively).Showsanticonvulsantandanti-bipolaractions.Blood-brainbarrierpermeable.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
- MolecularWeight256.09
- Chemicalstructure
![Lamotrigine [84057-84-1]](images/hellobio/201710/hb0368.png "Lamotrigine [84057-84-1]")
- MolecularFormulaC9H7Cl2N5
- CASNumber84057-84-1
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- Solubilityoverviewsolubleinethanol(10mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforLamotrigine
Modulationofcalciumandpotassiumcurrentsbylamotrigine.
GrunzeHetal(1998)Neuropsychobiology38(3):131-8.PubMedID:9778600LamotriginereducesspontaneousandevokedGABAAreceptor-mediatedsynaptictransmissioninthebasolateralamygdala:implicationsforitseffectsinseizureandaffectivedisorders.
BragaMFetal(2002)Neuropharmacology42(4):522-9.PubMedID:11955522Lamotrigineinhibitsmonoamineuptakeinvitroandmodulates5-hydroxytryptamineuptakeinrats.
SouthamEetal(1998)EurJPharmacol358(1):19-24.PubMedID:9809864Theanticonvulsivedruglamotrigineblocksneuronal{alpha}4{beta}2nicotinicacetylcholinereceptors.
ZhengCetal(2010)JPharmacolExpTher335(2):401-8.PubMedID:20688974
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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