Hello Bio/KT 5823/HB1316/250μg
商品编号：
HB1316-50μg
品牌：
hellobio
市场价：
¥1189.50
美元价：
915.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameKT5823
- ShortdescriptionPotent,selectivePKGinhibitor
- BIOLOGicaldescriptionPotentandselectiveproteinkinaseG(PKG)inhibitor(Ki=0.234µM).ExhibitsselectivityforPKGoverPKAandPKC(Kivaluesare>10.0and4.0µMforPKAandPKCrespectively).ArrestscellcycleatGO/G1boundaryandalsomodulatesNa+/I-symporter(NIS).Displayspro-apoptoticproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3",2",1"-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid,methylester
- MolecularWeight495.53
- MolecularFormulaC29H25N3O5
- CASNumber126643-37-6
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforKT5823
MultiplekinasearrestpointsintheG1phaseofnontransformedmammaliancellsareabsentintransformedcells.
GadboisDMetal(1992)ProcNatlAcadSciUSA89(18):8626-30.PubMedID:1528872KT5823differentiallymodulatessodiumiodidesymporterexpression,activity,andglycosylationbetweenthyroidandbreastcancercells.
BeyerSetal(2011)Endocrinology152(3):782-92.PubMedID:21209020GuanylylcyclaseinhibitorsNS2028andODQandproteinkinaseG(PKG)inhibitorKT5823triggerapoptoticDNAfragmentationinimmortalizeduterineepithelialcells:anti-apoptoticeffectsofbasalcGMP/PKG.
ChanSLetal(2003)MolHumReprod9(12):775-83.PubMedID:14614039
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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