Hello Bio/KT 5720/HB0361/100μg
商品编号：
HB0361-100μg
品牌：
hellobio
市场价：
¥1833.00
美元价：
1410.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
-
NameKT 5720
-
Short descriptionPotent, selective PKA inhibitor
-
Biological descriptionPotent and selective protein kinase A inhibitor (Ki = 60 nM). Arrests skin fibroblasts in the G1 stage. Reverses multi-drug resistance in leukaemia and attenuates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the dorsal root ganglion (DRG). Cell-permeable.
-
Biological actionInhibitor
-
Purity>98%
-
Our products in action1 citation Submit Your Citation Now
Images
Properties
-
Chemical name(9R,10S,12S)-2,3,9,10,11,12-Hexahyd ro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
-
Molecular Weight537.61
-
Chemical structure
![KT 5720 [108068-98-0]](images/hellobio/201710/hb0361.png "KT 5720 [108068-98-0]")
-
Molecular FormulaC32H31N3O5
-
CAS Number108068-98-0
-
PubChem identifier3844
-
SMILESCCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
-
InChiInChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)
-
InChiKeyZHEHVZXPFVXKEY-UHFFFAOYSA-N
-
MDL numberMFCD00132118
Storing and Using Your Product
-
Storage instructions-20°C (desiccate)
-
Solubility overviewSoluble in DMSO (50mM)
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for KT 5720
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.
Kase H et al (1987) Biochem Biophys Res Commun 142(2) : 436-40.PubMedID: 3028414In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: implications on hematological malignancies.
Galski H et al (2006) Leuk Res 30(9) : 1151-8.PubMedID: 16542724Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
Gadbois DM et al (1992) Proc Natl Acad Sci U S A 89(18) : 8626-30.PubMedID: 1528872Novel role of KT5720 on regulating hyperpolarization-activated cyclic nucleotide-gated channel activity and dorsal root ganglion neuron excitability.
Cheng Q et al (2013) DNA Cell Biol 32(6) : 320-8.PubMedID: 23713946
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
