Hello Bio/KN 92/HB0358/1mg
商品编号：
HB0358-1mg
品牌：
hellobio
市场价：
¥2008.50
美元价：
1545.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameKN92
- ShortdescriptionReducesCav1.2andCav1.3channelcurrents.InactiveanalogofKN93.
- BIOLOGicaldescriptionReducesCav1.2andCav1.3channelcurrents.InactiveanalogofKN93.Inhibitsnicotineandpotassiumstimulationoftyrosinehydroxylaseactivity.DisplaysnoactivityforCAMKIIandGLUT4.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-[N-(4"-Methoxybenzenesulfonyl)]amino-N-(4"-chlorophenyl)-2-propenyl-N-methylbenzylaminephosphate
- MolecularWeight554.98
- Chemicalstructure
![KN 92 [1135280-28-2]](images/hellobio/201710/hb0358.png "KN 92 [1135280-28-2]")
- MolecularFormulaC24H25ClN2O3S.H3PO4
- CASNumber1135280-28-2
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforKN92
CaMKII-independenteffectsofKN93anditsinactiveanalogKN92:reversIBLeinhibitionofL-typecalciumchannels.
GaoLetal(2006)BiochemBiophysResCommun345(4):1606-10.PubMedID:16730662CaMKactivationduringexerciseisrequiredforhistonehyperacetylationandMEF2AbindingattheMEF2siteontheGlut4gene.
SmithJAetal(2008)AmJPhysiolEndocrinolMetab295(3):E698-704.PubMedID:18647882TheCa++/calmodulin-dependentproteinkinaseIIinhibitorsKN62andKN93,andtheirinactiveanaloguesKN04andKN92,inhibitnicotinicactivationoftyrosinehydroxylaseinbovinechromaffincells.
MarleyPDetal(1996)BiochemBiophysResCommun221(1):15-8.PubMedID:8660326
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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