Hello Bio/KN-62/HB0359/
市场价：
¥565.50
美元价：
435.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameKN-62
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Short descriptionSelective CaM kinase II inhibitor. P2X7 receptor antagonist.
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Biological descriptionSelective CaM kinase II inhibitor (IC50 = 500 nM). Also potent, non-competitive P2X7 receptor antagonist (IC50 = 15 nM). Also inhibits GSK3β, PRAK and MAPKAP-K2. Cell-permeable, potential anticancer actions through suppression of HIF-1α.
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester
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Molecular Weight721.84
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Chemical structure
![KN-62 [127191-97-3]](images/hellobio/201710/hb0359.png "KN-62 [127191-97-3]")
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Molecular FormulaC38H35N5O6S2
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CAS Number127191-97-3
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PubChem identifier5312126
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SMILESCN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewsoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for KN-62
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.PubMedID: 10998351Effects of antagonists at the human recombinant P2X7 receptor.
Chessell IP et al (1998) Br J Pharmacol 124(6) : 1314-20.PubMedID: 9720806KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Tokumitsu H et al (1990) J Biol Chem 265(8) : 4315-20.PubMedID: 2155222
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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