Hello Bio/KN-62/HB0359/1mg
商品编号：
HB0359-1mg
品牌：
hellobio
市场价：
¥1345.50
美元价：
1035.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameKN-62
- ShortdescriptionSelectiveCaMkinaseIIinhibitor.P2X7receptorantagoNIST.
- BIOLOGicaldescriptionSelectiveCaMkinaseIIinhibitor(IC50=500nM).Alsopotent,non-competitiveP2X7receptorantagonist(IC50=15nM).AlsoinhibitsGSK3β,PRAKandMAPKAP-K2.Cell-permeable,potentialanticanceractionsthroughsuppressionofHIF-1α.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacidester
- MolecularWeight721.84
- Chemicalstructure
![KN-62 [127191-97-3]](images/hellobio/201710/hb0359.png "KN-62 [127191-97-3]")
- MolecularFormulaC38H35N5O6S2
- CASNumber127191-97-3
- PubChemidentifier5312126
- SMILESCN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforKN-62
Specificityandmechanismofactionofsomecommonlyusedproteinkinaseinhibitors.
DaviesSPetal(2000)BiochemJ351(Pt1):95-105.PubMedID:10998351EffectsofantagonistsatthehumanrecombinantP2X7receptor.
ChessellIPetal(1998)BrJPharmacol124(6):1314-20.PubMedID:9720806KN-62,1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine,aspecificinhibitorofCa2+/calmodulin-dependentproteinkinaseII.
TokumitsuHetal(1990)JBiolChem265(8):4315-20.PubMedID:2155222
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
