Hello Bio/Kenpaullone/HB1266/
市场价：
¥585.00
美元价：
450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameKenpaullone
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Short descriptionPotent CDK inhibitor. Also GSK-3 inhibitor. Generates iPSCs.
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Biological descriptionPotent, ATP-competitive CDK inhibitor (IC50 values are 0.4, 0.68, 7.5, 0.85 µM for CDK1/cyclinB, CDK2/cyclinA, CDK2/cyclinE and CDK5/p25 respectively). Also inhibits GSK-3β and LCK (IC50 values are 0.23 and 0.47 µM respectively) Displays reduced activity for other kinases (IC50 values are 15, 20, 20, 9 µM for c-src, casein kinase 2, ERK1 and ERK2 respectively). Also Generates iPSCs. Displays antiproliferative properties.
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
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Molecular Weight327.18
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Chemical structure
![Kenpaullone [142273-20-9]](images/hellobio/201710/hb1266.png "Kenpaullone [142273-20-9]")
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Molecular FormulaC16H11BrN2O
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CAS Number142273-20-9
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in DMSO (100mM, gentle warming) or ethanol (5mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Kenpaullone
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.
Zaharevitz DW et al (1999) Cancer Res 59(11) : 2566-9.PubMedID: 10363974The specificities of protein kinase inhibitors: an update.
Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.PubMedID: 12534346New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells.
Brault L et al (2005) Eur J Med Chem 40(8) : 757-63.PubMedID: 16122578
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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