你好Bio/Kenpaullone/HB1266/50mg
商品编号：
HB1266-50mg
品牌：
hellobio
市场价：
¥6903.00
美元价：
5310.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameKenpaullone
- ShortdescriptionPotentCDKinhibitor.AlsoGSK-3inhibitor.GeneratesiPSCs.
- BIOLOGicaldescriptionPotent,ATP-competitiveCDKinhibitor(IC50valuesare0.4,0.68,7.5,0.85µMforCDK1/cyclinB,CDK2/cyclinA,CDK2/cyclinEandCDK5/p25respectively).AlsoinhibitsGSK-3βandLCK(IC50valuesare0.23and0.47µMrespectively)Displaysreducedactivityforotherkinases(IC50valuesare15,20,20,9µMforc-src,caseinkinase2,ERK1andERK2respectively).AlsoGeneratesiPSCs.Displaysantiproliferativeproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
- MolecularWeight327.18
- Chemicalstructure
![Kenpaullone [142273-20-9]](images/hellobio/201710/hb1266.png "Kenpaullone [142273-20-9]")
- MolecularFormulaC16H11BrN2O
- CASNumber142273-20-9
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM,gentlewarming)orethanol(5mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforKenpaullone
Discoveryandinitialcharacterizationofthepaullones,anovelclassofsmall-moleculeinhibitorsofcyclin-dependentkinases.
ZaharevitzDWetal(1999)CancerRes59(11):2566-9.PubMedID:10363974Thespecificitiesofproteinkinaseinhibitors:anupdate.
BainJetal(2003)BiochemJ371(Pt1):199-204.PubMedID:12534346Newthiopheneanaloguesofkenpaullone:synthesisandbiologicalevaluationinbreastcancercells.
BraultLetal(2005)EurJMedChem40(8):757-63.PubMedID:16122578
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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