Hello Bio/KC 12291 hydrochloride/HB1019/10mg
商品编号：
HB1019-10mg
品牌：
hellobio
市场价：
¥1482.00
美元价：
1140.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameKC12291hydrochloride
- ShortdescriptionAtypicalvoltage-gatedsodiumchannelblocker
- BIOLOGicaldescriptionAtypicalvoltage-gatedsodiumchannelblocker.ReducessustainedNa+channelcurrentandinhibitspeakcurrent.Inhibitsveratridine-andLPC-inducedsustainedsodiumcurrentcontractures(IC50valuesare0.55and0.79µMrespectively).Showscardioprotective,antiischemicandbradycardicactions.
- BiologicalactionBlocker
- Purity>97%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiADIazol-3-yl)oxy]propyl]benzeneethanaminehydrochloride
- MolecularWeight449.99
- Chemicalstructure
![KC 12291 hydrochloride [181936-98-1]](images/hellobio/201710/hb1019.png "KC 12291 hydrochloride [181936-98-1]")
- MolecularFormulaC22H27N3O3S.HCl
- CASNumber181936-98-1
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- Solubilityoverviewsolubleinwater(25mM)orDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforKC12291hydrochloride
KC12291:anatypicalsodiumchannelblockerwithmyocardialantiischemicproperties.
JohnGWetal(2004)CardiovascDrugRev22(1):17-26.PubMedID:14978516Pharmacologicalcharacterisationofsodiumchannelsinsinoatrialnodepacemakingintheratheart.
LétienneRetal(2006)EurJPharmacol530(3):243-9.PubMedID:16368090Anti-ischemiccompoundKC12291preventsdiastoliccontractureinisolatedatriabyblockadeofvoltage-gatedsodiumchannels.
TamareilleSetal(2002)JCardiovascPharmacol40(3):346-55.PubMedID:12198320
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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