Hello Bio/KB-R7943 mesylate/HB1133/
市场价：
¥1950.00
美元价：
1500.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameKB-R7943 mesylate
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Short descriptionSelective, reverse mode Na+ / Ca2+ exchange inhibitor
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Biological descriptionSelective, reverse mode Na+/Ca2+ exchange inhibitor (IC50 = 0.7 µM). Also potent mitochondrial Ca2+ uniporter inhibitor (Ki = 5.5 µM). Does not affect Na+-dependent transport systems or ionotropic glutamate receptors. Decreases nitric oxide and hydoxyradical formation. Displays cardioprotective properties.
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate
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Molecular Weight427.49
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Chemical structure
![KB-R7943 mesylate [182004-65-5]](images/hellobio/201710/hb1133.png "KB-R7943 mesylate [182004-65-5]")
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Molecular FormulaC16H17N3O3S.CH3SO3H
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CAS Number182004-65-5
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for KB-R7943 mesylate
The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.
Santo-Domingo J et al (2007) Br J Pharmacol 151(5) : 647-54.PubMedID: 17471180Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.
Hoyt KR et al (1998) Mol Pharmacol 53(4) : 742-9.PubMedID: 9547366Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.
Maczewski M et al (2003) Eur J Pharmacol 461(2-3) : 139-47.PubMedID: 12586209
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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