Hello Bio/KB-R7943 mesylate/HB1133/50mg
商品编号：
HB1133-50mg
品牌：
hellobio
市场价：
¥6123.00
美元价：
4710.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameKB-R7943mesylate
- ShortdescriptionSelective,reversemodeNa+/Ca2+exchangeinhibitor
- BIOLOGicaldescriptionSelective,reversemodeNa+/Ca2+exchangeinhibitor(IC50=0.7µM).AlsopotentmitochondrialCa2+uniporterinhibitor(Ki=5.5µM).DoesnotaffectNa+-dependenttransportsystemsorionotropicglutamatereceptors.DecreasesnitricoxideandhydoxyrADIcalformation.Displayscardioprotectiveproperties.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate
- MolecularWeight427.49
- Chemicalstructure
![KB-R7943 mesylate [182004-65-5]](images/hellobio/201710/hb1133.png "KB-R7943 mesylate [182004-65-5]")
- MolecularFormulaC16H17N3O3S.CH3SO3H
- CASNumber182004-65-5
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforKB-R7943mesylate
TheplasmamembraneNa+/Ca2+exchangeinhibitorKB-R7943isalsoapotentinhibitorofthemitochondrialCa2+uniporter.
Santo-DomingoJetal(2007)BrJPharmacol151(5):647-54.PubMedID:17471180ReverseNa+/Ca2+exchangecontributestoglutamate-inducedintracellularCa2+concentrationincreasesinculturedratforebrainneurons.
HoytKRetal(1998)MolPharmacol53(4):742-9.PubMedID:9547366RoleofnitricoxideandfreeradicalsincardioprotectionbyblockingNa+/H+andNa+/Ca2+exchangeinratheart.
MaczewskiMetal(2003)EurJPharmacol461(2-3):139-47.PubMedID:12586209
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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