Hello Bio/K252c/HB0353/1mg
市场价：
¥1014.00
美元价：
780.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameK252c
- ShortdescriptionPKCinhibitor
- BIOLOGicaldescriptionProteinkinaseC(PKC)inhibitorwithselectivityoverproteinkinaseA(IC50value=214nMatPKC).Inhibitsβ-lactamase,malatedehydrogenaseandchymotrypsin(IC50valuesare8,8and10µMrespectively).Inhibitshumancytomegalovirusandamyloidβfibrillization.Showscytotoxicandanti-tumoractions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
- MolecularWeight311.34
- Chemicalstructure
![K252c [85753-43-1]](images/hellobio/201710/hb0353.png "K252c [85753-43-1]")
- MolecularFormulaC20H13N3O
- CASNumber85753-43-1
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforK252c
ProteinkinaseCinhibitors;structure-activityrelationshipsinK252c-relatedcompounds.
FabreSetal(1993)BioorgMedChem1(3):196-6.PubMedID:8081852IndolocarbazolesexhibitstrongantiviralactivityagainsthumancytomegalovirusandarepotentinhibitorsofthepUL97proteinkinase.
ZimmermannAetal(2000)AntiviralRes48(1):49-60.PubMedID:11080540Kinaseinhibitors:notjustforkinasesanymore.
McGovernSLetal(2003)JMedChem46(8):1478-83.PubMedID:12672248K-252b,candd,potentinhibitorsofproteinkinaseCfrommicrobialorigin.
NakanishiSetal(1986)JAntibiot(Tokyo)39(8):1066-71.PubMedID:3759658
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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